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Dr Seonaidh Cotton

Dr Seonaidh Cotton
Dr Seonaidh Cotton
Dr Seonaidh Cotton

BSc (Hons), MLitt, PhD

Head of Trial Management

黑料网
Email Address
s.c.cotton@abdn.ac.uk
Telephone Number
+44 (0)1224 438178
Office Address
Aberdeen Centre for Evaluation, Third floor, Health Sciences Building
Foresterhill Campus
Foresterhill
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU in 2007 as a trial manager.  I graduated from the 黑料网 with a BSc in Health Sciences in 1993, an MLitt in 1995, and a PhD in 2007.  Prior to joining the Unit, I worked in the Department of Public Health at the 黑料网.

I am Head of Trial Management/Senior Trial Manager within CHaRT supporting the portfolio of trials.      

Previously I was the Deputy Senior Trial Manager and supported a number of studies including RAACENO, EMPOWER and ELECTRIC (all now completed).  I also worked as trial manager on a number of CHaRT trials, including ALLEGRO, BICS, TWICS, CLASS, NIAMI, FOCCUS, REFLUX and the Cysteamine in CF study.  

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

 

Qualifications

  • BSc Health Sciences 
    1993 - 黑料网 
  • MLitt by research 
    1994 - 黑料网 
  • PhD Public Health 
    2008 - 黑料网 
Research

Research Overview

Trial methodology & trial management

Research Areas

Applied Health Sciences

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Nutrition and Health

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Current Research

I am the Senior Trial Manager within CHaRT supporting the portfolio of trials.   I also currently work on the BICS trial - a multicentre trial investigating the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.    

I am interested in methodological research that can be carried out alongside existing trials, including the provision of information to potential participants and strategies to increase response rates.

Past Research

Since joining the Unit I have worked on a number of trials that have now been completed. 

TWICS  - a multicentre trial investigating the effectiveness of low dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease.

CLASS - a multicentre trial comparing foam sclerotherapy and endovenous laser ablation with conventional surgery in patients with varicose veins;

NIAMI - a phase II multicentre trial investigating whether an intravenous injection of sodium nitrite given immediately before the infarct related artery is opened reduces ischaemia reperfusion injury in patients with myocardial infarction;

FOCCUS - a pragmatic multi-centred randomised controlled trial of surgical HDU care versus HDU care delivered in an ICU and pre-operative fluid loading in high-risk patients undergoing major elective surgery

REFLUX - a multi-centre randomised trial comparing a policy of relatively early laparoscopic surgery with a continued best medical management policy for people with more severe gastro-oesophageal reflux disease.

The Cysteamine in CF study - a single-centre, single group open label study of oral cysteamine in patients with Cystic Fibrosis.

I also supported RAACENO, EMPOWER and ELECTRIC (all now completed) as senior trial manager.

Teaching

Courses

Teaching Responsibilities

I have supervised a number of undergraduate and Masters level research projects, including topics such as provision of information to potential participants, strategies to increase response rates, and outcome measures.

 

 

Non-course Teaching Responsibilities

Outwith the University, I am a faculty member on the Edinburgh Clinical Trial Management Course ().

 

Publications

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  • Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation

    Gillies, K., Huang, W., Skea, Z., Brehaut, J., Cotton, S.
    Trials, vol. 15, 62
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Nitrites in Acute Myocardial Infarction

    Siddiqi, N., Bruce, M., Neil, C. J., MacLennan, G., Cotton, S., Papadopoulou, S. A., Jagpal, B., Brown, S., Gonzalez, F. P., Singh, S., Schwarz, K., Feelisch, M., Bunce, N., Lim, P. O., Hildick-Smith, D., Horowitz, J., Madhani, M., Boon, N., Dawson, D., Kaski, J., Frenneaux, M. P.
    Circulation, vol. 128, no. 24, pp. 2705
    Contributions to Journals: Abstracts

  • Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy

    Whynes, D. K., Sharp, L., Cotton, S. C., Cruickshank, M., Gray, N. M., Little, J., Waugh, N.
    European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 169, no. 1, pp. 88-92
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Clinical and economic evaluation of laparoscopic surgery compared with medical management for gastro-oesophageal reflux disease: 5-year follow-up of multicentre randomised trial (the REFLUX trial)

    Grant, A. M., Boachie, C., Cotton, S. C., Faria, R., Bojke, L., Epstein, D. M., Ramsay, C. R., Corbacho, B., Sculpher, M., Krukowski, Z. H., Heading, R. C., Campbell, M. K.
    Health Technology Assessment, vol. 17, no. 22, pp. 1-166
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

    Siddiqi, N., Bruce, M., Neil, C. J., Jagpal, B., MacLennan, G. S., Cotton, S. C., Papadopoulo, S. A., Bunce, N., Lim, P., Schwarz, K., Singh, S., Hildick-Smith, D., Horowitz, J. D., Madhani, M., Boon, N., Kaski, J., Dawson, D., Frenneaux, M. P.
    Journal of translational medicine, vol. 11, 116
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX)

    Grant, A. M., Cotton, S. C., Boachie, C., Ramsay, C. R., Krukowski, Z. H., Heading, R. C., Campbell, M. K., REFLUX Trial Group
    BMJ, vol. 346, f1908
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial

    Sharp, L., Cotton, S., Thornton, A., Gray, N., Whynes, D., Smart, L., Waugh, N., Duncan, I., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Cytopathology, vol. 23, no. 3, pp. 150-160
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study

    Cuthbertson, B. H., Campbell, M. K., Stott, S. A., Elders, A., Hern谩ndez, R., Boyers, D., Norrie, J., Kinsella, J., Brittenden, J., Cook, J., Rae, D., Cotton, S. C., Alcorn, D., Addison, J., Grant, A., The FOCCUS study group
    Critical Care, vol. 15, no. 6, R296
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Analysis of patient information leaflets (PILs), used in clinical trials using the Informed Consent Evaluation instrument (ICEi)

    Gillies, K., Skea, Z. C., Huang, W., Cotton, S. C.
    Trials, vol. 12, no. Suppl 1, pp. A121
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Human papillomavirus infection and anxiety: analyses in women with low-grade cervical cytological abnormalities unaware of their infection status

    Johnson, C. Y., Sharp, L., Cotton, S. C., Harris, C. A., Gray, N. M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    PloS ONE, vol. 6, no. 6, e21046
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Long-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial

    Sharp, L., Cotton, S., Gray, N., Avis, M., Russell, I., Walker, L., Waugh, N., Whynes, D., Woolley, C., Thornton, A. J., Smart, L., Cruickshank, M., Little, J., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 104, no. 2, pp. 255-264
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial

    Cotton, S., Sharp, L., Little, J., Cruickshank, M., Seth, R., Smart, L., Duncan, I., Harrild, K., Neal, K., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 117, no. 6, pp. 645-659
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery

    Cuthbertson, B., Campbell, M. K., Stott, S., Vale, L. D., Norrie, J. D. T., Kinsella, J., Cook, J. A., Brittenden, J., Grant, A. M., Alcorn, D., Serpell, M., McColl, S., Rae, D., Shepherd, K., Addison, J., McPherson, G. C., McDonald, A. M., Cotton, S. C., Elders, A. S., MacLennan, G. S., Boyers, D., Hern谩ndez, R. A.
    Edinburgh, United Kingdom: Chief Scientist Office. 7 pages
    Books and Reports: Commissioned Reports

  • After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial

    Sharp, L., Cotton, S. C., Cochran, C., Gray, N. M., Little, J., Neal, K., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 11, pp. 1506-1514
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Comprehensive cancer control-research & development: Knowing what we do and doing what we know

    Kerner, J. F., Cazap, E., Yach, D., Pierotti, M. A., Daidone, M. G., De Blasio, P., Geary, P., Schacter, B., Sant, M., Habbema, J. D. F., Sankaranarayanan, R., Sutcliffe, C., Sutcliffe, S., Kaijage, J. K., Scanlan, P. A., Gibson, S., Mes-Masson, A. M., Sawyer, M., Shepherd, L., Watson, P., Zanke, B., Small, I. A., Olmedo, D. B., Breitenbach, M. D., Santini, L. A., Maltoni, L. A., Ramalho, D., Ferreira, C. G., Sharp, L., Cruickshank, M., Smart, L., Harrild, K., Waugh, N., Little, J., Seth, R., Neal, K., Duncan, I., Ioka, A., Ito, Y., Sato, N., Tsukuma, H., Li, J., Zhang, B. N., Fan, J. H., Qiao, Y. L., Zhong, H. Y., Curado, M. P., Pontes, T. J., Peacock, S., Van Der Hoek, K., Hoch, J., Musa, Z., Weir, H. K., Friedman, C., German, R., Ceilleachair, A. O., Comber, H., Cotton, S., Tilson, L., Walsh, C., Usher, C., Barry, M., Chilcott, J., Tappenden, P., Whyte, S., Staines, A., Greenberg, A., Fairclough, L., Roberts, W., Masterson Tavares Pereira Ferrera, D., Fonseca, E. R., Casado, L., McBride, M. L., Goddard, K., Lorenzi, M., Spinelli, J. J., Broemeling, A. M., Glickman, V., Pritchard, S., Siegel, L., Rogers, P. C., Sheps, S., Annunziata, M. A., Giovannini, L., Bianchet, K., Muzzatti, B., Berretta, M., Lleshi, A., Tirelli, U., Sisimayi, C. N., Sarwal, K., Torrance, H., Baili, P., Amati, C., Di Salvo, F., Frazzingaro, C., Sanz, N., Micheli, A.
    Tumori, vol. 95, no. 5, pp. 610-622
    Contributions to Journals: Articles
    • [ONLINE]

  • Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial

    Sharp, L., Cruickshank, M., Little, J., Cotton, S., Harrild, K., Cochran, C., Duncan, I., Gray, N., Hammond, R., Smart, L., Thornton, A., Waugh, N., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, b2548
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial

    Little, J., Sharp, L., Cotton, S., Cruickshank, M., Duncan, I., Harrild, K., Jenkins, D., Smart, L., Waugh, N., Cochran, C., Gray, N., Hammond, R., Neal, K., Thornton, A. J., Woolley, C., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, b2546
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Options for managing low grade cervical abnormalities detected at screening: cost effectiveness study

    Whynes, D., Philips, Z., Woolley, C., Cotton, S., Cruickshank, M., Harrild, K., Little, J., Neal, K., Sharp, L., Waugh, N., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Medical Journal, vol. 339, no. -, b2549
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake

    Sharp, L., Little, J., Brockton, N. T., Cotton, S. C., Masson, L. F., Haites, N. E., Cassidy, J.
    British Journal of Nutrition, vol. 99, no. 2, pp. 379-389
    Contributions to Journals: Articles
    • [ONLINE] DOI:
    • [OPEN ACCESS]

  • Lifestyle and sociodemographic factors associated with high-risk HPV infection in UK women

    Cotton, S. C., Sharp, L., Seth, R., Masson, L. F., Little, J., Cruickshank, M. E., Neal, K., Waugh, N. R., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 97, no. 1, pp. 133-139
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1

    Little, J., Sharp, L., Masson, L. F., Brockton, N. T., Cotton, S. C., Haites, N. E., Cassidy, J.
    International Journal of Cancer, vol. 119, no. 9, pp. 2155-2164
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears)

    Sharp, L., Cotton, S. C., Alexander, L., Williams, E., Gray, N. M., Reid, J. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Clinical Trials, vol. 3, pp. 431-442
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Trial of management of borderline and other low grade abnormal smears (TOMBOLA): Trial design

    Cotton, S. C., Sharp, L., Little, J., Cruickshank, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Contemporary Clinical Trials, vol. 27, no. 5, pp. 449-471
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Enclosing a pen with a postal questionnaire can significantly increase the response rate

    Sharp, L., Cochran, C., Cotton, S. C., Gray, N. M., Gallagher, M. E., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    Journal of Clinical Epidemiology, vol. 59, no. 7, pp. 747-754
    Contributions to Journals: Articles
    • [ONLINE] DOI:

  • Psychological effects of a low-grade abnormal cervical smear test result:anxiety and associated factors

    Gray, N. M., sharp, L., Cotton, S. C., Masson, L. F., little, J., Walker, L. G., Avis, M., Philips, Z., Russell, I., Whynes, D. K., Cruickshank, M. E., Woolley, C. M., The TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) Group
    British Journal of Cancer, vol. 94, pp. 1253-1262
    Contributions to Journals: Articles
    • [ONLINE] DOI:
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