BSc (Hons) Genetics, PhD
Research Fellow
- ºÚÁÏÍø
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- Email Address
- g.mcilroy@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition




Biography
09/2026 - Present: Research Fellow, ºÚÁÏÍø
09/2021 - 09/2026: Diabetes UK RD Lawrence Fellow, ºÚÁÏÍø
03/2019 - 06/2021: Diabetes UK Postdoctoral Research Fellow, ºÚÁÏÍø
03/2018 - 03/2019: Wellcome Trust ISSF Research Fellow, ºÚÁÏÍø
12/2014 - 03/2018: MRC Postdoctoral Research Fellow, ºÚÁÏÍø
10/2010 - 12/2014: PhD, ºÚÁÏÍø
09/2005 - 09/2009: BSc (Hons) Genetics, University of Glasgow
Qualifications
- PhD Integrative Physiology2014 - ºÚÁÏÍø
- BSc Genetics (Hons)2009 - University of Glasgow
Memberships and Affiliations
- Internal Memberships
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Rowett Institute Conflict of Interest Panel (2025 - Present)
BSU Team Committee Member (2019 - Present, Academic representative)
Rowett Institute Tissue Culture Facility Team (2024 - Present, Academic lead)
- External Memberships
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Diabetes UK Research Committee Member (2026 - Present, Observer)
(2015 - Present, Professional Member)
Latest Publications
AAV-mediated delivery of leptin but not adiponectin improves metabolic health in a pre-clinical mouse model of congenital generalised lipodystrophy
Gene TherapyContributions to Journals: Articles- [ONLINE] DOI:
Hydroxysteroid 17-beta dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice
Experimental Physiology, vol. 110, no. 8, pp. 1071-1086Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee
Osteoarthritis and Cartilage, vol. 32, no. 12, pp. 1552-1565Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy
Gene Therapy, vol. 31, pp. 445–454Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip), Pisa, Italy, 28–29 September 2023
Contributions to Journals: Conference Articles- [ONLINE] DOI:
- [ONLINE]
Prizes and Awards
Diabetes UK Innovators in Diabetes 2024 - Presentation Winner
- Research
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Research Overview
I am interested in the development and function of adipose tissue (body fat). In conditions such as obesity, adipose tissue becomes dysfunctional and no longer safely stores dietary fats. This can lead to severe metabolic complications such as diabetes, fatty liver, cardiovascular disease and some cancers.
Some people are unable to make adipose tissue. These rare disorders are known as lipodystrophies. Here, the lack of body fat and inability to safely store dietary fats causes similar metabolic complications to those observed in obesity. For more information on lipodystrophies, visit the , the UK’s only charity dedicated to supporting people affected by Lipodystrophy, which is a rare and life threatening disease affecting approximately 1 in 1 million people across the world.
My current research utilises mouse models of lipodystrophy to investigate this disorder. My aim is to discover novel therapeutic treatment strategies for patients suffering from lipodystrophy. However, rare disorders such as lipodystrophy can also be used to identify new treatments for more common forms of type 2 diabetes often observed in conditions of obesity.

Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Molecular Biology
- Animal Physiology
- Endocrinology
- Diabetes
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is , published under the licence.
Knowledge Exchange
Lipodystrophy UK Patient Day (27/03/2026)
Invited speaker


Bucksburn Academy S3 Life Science Class Visit (10/12/2025)
An introduction to the polymerase chain reaction: PCR


(09/09/25)
Co-organised and hosted at the Rowett Institute as part of the UKCO meeting held in Aberdeen
Rowett Institute “Doors Open Day” (06/09/2025)
Tours of the building to members of the public
Kemnay Academy Advanced Higher Biology/Science Baccalaureate Visit (01/02/2023)
PCR practical and Scientific Poster workshop


Invited speaker (21/05/2019)
Aberdeen, Scotland
Cell Block Science Interactive stall (24/10/2018)
HMP Grampian
Interactive stall (28/09/2018)
Aberdeen Science Centre
Supervision
Ms Mansi Tiwari joined the Mcilroy lab in October 2022 to commence her PhD. Here she will combine gene therapy and cutting edge multiomic next generation sequencing analysis at single cell resolution to identify novel treatments for type 2 diabetes.

Funding and Grants
(£263,093, Co-I)
Better treatments for lipoatrophic diabetes: GLP-1 based drugs and leptin gene therapy
Daisy Duncan Legacy Award for Cardiac Research 2025 (£10,000, PI)
New Drivers of Hypertrophic Cardiomyopathy
(£495,283, PI)
Exploiting gene therapy to discover treatments for type 2 diabetes
Wellcome Trust ISSF Seed Corn Fund 2020 (£17,469, Co-I)
Developing viral therapeutics for the treatment of severe diabetes and metabolic disease in lipodystrophy.
10X Genomics/illumina core facility grant @ CGEBM 2019 (~£10,000, PI)
Adipose tissue chromatin profiling in generalised lipodystrophy at single cell resolution
(€50,000, PI)
Identifying Novel Therapies to Prevent Diabetes in Congenital Lipodystrophy.
Wellcome Trust ISSF Fellowship Support Award 2018 (£60,000, PI)
Does Bscl2 disruption in the liver contribute to metabolic dysfunction in lipodystrophy?
- Teaching
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Teaching Responsibilities
MSc Human Nutrition - Molecular Nutrition (RN5502)
Molecular Biology of Lipodystrophy
MSc Diabetes and Metabolism (BM5502)
Sleeve gastrectomy data analysis tutorial
Research Skills For Medical Sciences (SM2501)
Tutor for disease tutorial
Non-course Teaching Responsibilities
Personal Tutor (2026 - Present)
- Publications
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Page 2 of 3 Results 11 to 20 of 26
Bscl2 Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy
Journal of Clinical Medicine, vol. 10, no. 3, 441Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation
Scientific Reports, vol. 10, 3259Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Ablation of Bscl2/Seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy
Disease Models & Mechanisms, vol. 13, no. 1, dmm042655Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
- [ONLINE]
Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet
Scientific Reports, vol. 8, 17863Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease
Molecular Metabolism, vol. 10, pp. 55-65Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
Scientific Reports, vol. 7, 43782Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Elevated fibroblast growth factor 21 (FGF21) levels in obese, insulin resistant states are normalised by fenretinide treatment via retinoic acid signalling
Diabetic Medicine, vol. 33, pp. 48Contributions to Journals: Abstracts- [ONLINE] DOI:
Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
Biochemical Pharmacology, vol. 100, pp. 86-97Contributions to Journals: Articles- [ONLINE] DOI:
- [OPEN ACCESS]
Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen-signaling
Obesity, vol. 23, no. 8, pp. 1655-1662Contributions to Journals: Articles- [ONLINE] DOI:
Mechanisms of improved glucose homeostasis by the synthetic retinoid fenretinide: altered genes, metabolites and lipids
Diabetic Medicine, vol. 32, no. S1, pp. 47-48Contributions to Journals: Abstracts- [ONLINE] DOI: